Introduction to Angiogenesis and Bill’s Protocol

Angiogenesis is the process by which tumors attract new blood vessels to themselves.   Tumor cells that aren’t getting enough oxygen from the blood are hypoxic, and make vascular growth factors.   Vascular growth factors are substances involved in making new blood vessels grow to the tumor.   If the tumor cannot get an adequate blood supply, it cannot grow larger.

Here is a video of Dr. Judah Folkman, who is the Father of Angiogenesis and Antiangiogenesis, explaining the antiangiogenic approach to cancer treatment.

http://www.youtube.com/watch?v=UdtSej78fF8

In normal bodies, vascular growth factors are balanced by endogenous angiogenesis inhibitors…  these are substances that the body makes itself, that counteract the effects of the vascular growth factors, or prevent their production.  These angiogenesis inhibitors prevent tumors from growing, and prevent many inflammatory conditions as well.   As often is found in the body, there are opposing  forces, and the balance between opposing forces often decides whether there is normal functioning, or a disease process occurring.

Tumor blood vessels are more fragile than normal blood vessels and break easily.  As time goes by, these vessels break. [High-grade tumors tend to make more fragile blood vessels, and make them more quickly, than low-grade tumors.] If the tumor cannot grow new blood vessels, the tumor tissue that was nourished by these blood vessels dies, and is reabsorbed.  The tumor will then eventually shrink to a lump that is under 2mm, which is about what can survive without its own blood supply.   These avascular lumps just sit there.   Should the body lose its ability again to make the endogenous angiogenesis inhibitors, [angiostatin, endostatin, tumstatin, etc] then the lump will grow again.

http://www.pbs.org/wgbh/nova/cancer/folkman.html

http://clincancerres.aacrjournals.org/cgi/content/full/5/11/3516

Bill’s cocktail contains a lot of substances that act as angiogenesis inhibitors.  These, when taken in reasonable and nontoxic doses, may create a multi-pronged attack on the ability of the tumor to grow new blood vessels. It is not one or two or even three antiangiogenic agents taken to toxic levels, but a multiple agent cocktail, only using over-the-counter substances, especially if there is no active disease.  The combination of agents may allow a more effective widespread approach to angiogenesis inhibition, instead of targeting one or a few pathways.  The widespread approach may also prevent resistance developing.  Hopefully the many different inhibitors will tip the body’s balance toward angiogenesis inhibition.

http://www.ncbi.nlm.nih.gov/sites/entrez       Plug in search box, just the numbers.

PMID: 14695206

PMID: 15648195

PMID: 15523106

PMID: 11425277

PMID: 12202894

PMID: 15523104

IF there is active disease, meaning there is tumor present, then using metronomic dosing of cytotoxic drugs will give a better response.

Metronomic dosing of cytotoxics means they are given in a low daily dose. This is designed to kill the reproducing endothelial cells [the lining cells of the blood vessels that are growing toward the tumor].  Cytoxan [cyclophosphamide] is one of the drugs used.  Cytoxan also raises thrombospondin-1, which is a potent and endothelial-specific inhibitor of angiogenesis.

http://www.ncbi.nlm.nih.gov/sites/entrez   Plug in search box the numbers: 14561896

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