Bill Peeples’ Angiogenesis Inhibitor Cocktail
ANGIOGENESIS and the Bill Peeples’ Angiogenesis Inhibitor Cocktail
Angiogenesis is the process by which tumors attract new blood vessels to themselves. Tumor cells that aren’t getting enough oxygen from the blood are hypoxic, and make vascular growth factors. Vascular growth factors are substances involved in making new blood vessels grow to the tumor. If the tumor cannot get an adequate blood supply, it cannot grow larger.
Here is a link to some videos of Dr. Judah Folkman, who is the Father of Angiogenesis and Antiangiogenesis, explaining the antiangiogenic approach to cancer treatment.
In normal bodies, vascular growth factors are balanced by endogenous angiogenesis inhibitors… these are substances that the body makes itself, that counteract the effects of the vascular growth factors, or prevent their production. These angiogenesis inhibitors prevent tumors from growing, and prevent many inflammatory conditions as well. As often is found in the body, there are opposing forces, and the balance between opposing forces often decides whether there is normal functioning, or a disease process occurring.
Tumor blood vessels are more fragile than normal blood vessels and break easily. As time goes by, these vessels break. [High-grade tumors tend to make more fragile blood vessels, and make them more quickly, than low-grade tumors.] If the tumor cannot grow new blood vessels, the tumor tissue that was nourished by these blood vessels dies, and is reabsorbed. The tumor will then eventually shrink to a lump that is under 2mm, which is about what can survive without its own blood supply. These avascular lumps just sit there. Should the body lose its ability again to make the endogenous angiogenesis inhibitors, [angiostatin, endostatin, tumstatin, etc] then, the lump will grow again.
Use this link: http://www.ncbi.nlm.nih.gov/pubmed/?term=14688711
(Throughout this paper there are references to many study publications that support what is recommended. These medical studies are stored at www.PubMed.gov )
Here is a Nova special, in transcript form, that interview Dr. Judah Folkman and his angiogenesis discoveries.
This article is about angiogenesis and solid tumors published in Clinical Cancer Research Magazine:
Bill’s cocktail contains a lot of substances that act as angiogenesis
Inhibitors. These, when taken in reasonable and nontoxic doses, may create a multi-pronged attack on the ability of the tumor to grow new blood vessels. It is not one or two or even three antiangiogenic agents taken to toxic levels, but a multiple agent cocktail, only using over-the-counter substances, especially if there is no active disease. The combination of agents may allow a more effective widespread approach to angiogenesis inhibition, instead of targeting one or a few pathways. The widespread approach may also prevent resistance developing. Hopefully the many different inhibitors will tip the body’s balance toward angiogenesis inhibition.
IF there is active disease, meaning there is tumor present, then using
metronomic dosing of cytotoxic drugs will give a better response.
Metronomic dosing of cytotoxics means they are given in a low daily dose. This is designed to kill the reproducing endothelial cells [the lining cells of the blood vessels that are growing toward the tumor]. Cytoxan [cyclophosphamide] is one of the drugs used. Cytoxan also raises thrombospondin-1, which is a potent and endothelial-specific inhibitor of angiogenesis.
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Bill’s cocktail also has some agents that affect the immune system… for instance, Tagamet encourages killer cell activity.
We have had some people go into remission on this cocktail. HOWEVER, there are caveats [effects to be aware of]:
1. LARGE tumors produce a LOT of growth factors [VEGF, EGF, PDGF, etc] locally. It might not be possible to get enough angiogenesis inhibitors in the general area of the tumors to counteract a massive production of local growth factors. Larger and higher-grade tumors will produce larger amounts of local growth factors. Certainly attacking the endothelial cells will help, but you will need time to get enough inhibitors to the tumor. There has not been notable success when there is a lot of large tumors… and usually these people are trying the cocktail as a last resort, since they are too weak and their oncologists refuse further chemo… this is often tried within a month of death. [“I don’t think that most agents work well when tumors are very large and growing fast. However, Gleevec did work on people who were in hospice, and these people are still alive today. So, it may be difficult to draw any hard and fast rules here, even when tumors are large and out of control. Doctordee” ]
But the side effect profile of the cocktail is very favorable. it is tolerated well, generally, without nausea, vomiting, diarrhea, blood count lowering, etc. So, it is generally safe. There are many agents to choose from, so if there is a reaction to one, a different one can be substituted. You generally want a large selection of agents that hit various growth factors, not just one of the factors.
See Addendum about diet.
2. Stop angiogenic inhibitors a week prior to surgery. Afterwards, keep off them for 2 to 4 weeks, depending upon the extent of the surgery. You do not wish to inhibit the healing of your surgical wounds. (See addendum about benefits of staying on a ketogenic diet.)
3. Stopping angiogenic inhibitors can result in an increase in growth of the tumor. Either have the next treatment ready, or re-institute the cocktail with or without the low dose cytotoxics, until the tumor stops growing. Cytotoxics are only used for a few months at a time, usually. (See addendum about benefits of staying on high ketogenic diet.)
4. ALWAYS tell your doctors what you are taking. ALWAYS check what you are taking with your cancer doctors if they are instituting treatment of any type… surgery, chemo or radiation, or other..
5. This is a management protocol. It will not cure cancer. It will not make the cancer disappear microscopically. But it might keep growth from occurring, and might allow tumors to shrink to small avascular lumps that do not threaten life.
6. VARIATIONS OF THE COCKTAIL
Check all substances you take, or plan to take, for interactions, and check them with any other supplements or drugs you may be taking. There is a section on drug interactions further on. There are drug interaction checkers available online, use www.google.com to find them. Use more than one reputable checker in order to be sure.
There is the Basic Cocktail with or without copper control. [No known tumor present]
There is the Cytotoxic Metronomic Dosing addition for tumor treatment [Active Disease Treatment].
There is the Additional Drugs for Improved Response during Active DiseaseTreatment.
There is a list of Prescription Agents, which can be added for chronic conditions at any time.
Essentially, you are starting the cocktail to keep the balance in your body toward angiogenesis inhibition. If tumor appears or grows, increasing agents and strength of agents increases the body’s balance toward angiogenesis inhibition.
FOLLOW THE COPPER TRAIL
Copper levels go up when tumors are about to become active… If your copper levels are high, go on the Basic Cocktail with attention especially to Curcumin, Zinc, NAC, and Tetrathiomolybdate, until copper levels are low normal at least, and the Zn/Cu ration favors zinc. Once the copper levels are stabilized at the very low end of normal, then you can very, very slowly taper doses. If the copper levels start climbing again, add appropriate doses of curcumin, NAC, and zinc until the copper comes under control.
You can actually talk with Bill Peeples.
Email him, and he will send you his telephone number so you can call and discuss angiogenesis inhibition and the cocktail with him. Bill does not charge for this service, nor does he sell agents or ingredients of the cocktail. He does not make money from this service.
We are not oncologists. We are not practicing medicine. Information provided here is for discussion between you and your doctors. We strongly recommend that your treating doctors be consulted regularly.