The Cocktail for Active Disease, part two

LIST OF PRESCRIPTION AGENTS

[including those for chronic conditions]

Some of these agents might already be prescribed for a condition of the patient’s already.  Or can be substituted for ones that are…

YOU MUST BE UNDER A DOCTOR”S SUPERVISION.  DO NOT USE CYTOTOXIC AGENTS UNLESS THERE IS TUMOR PRESENT.

Name                               Dose      Mechanism of Action

__________________________________________________

1. Biaxin (Clarithromycin)   500mg twice daily

Or (Zythromax)              500mg BID

These drugs inhibit the production of Interlukin-6, which is a promoter of tumor cell proliferation and angiogenesis.

[do not take with NAC, it may inhibit absorption]

Or any one of these Antibiotics

Or Minocyline               100mg BID

Or Doxycycline              250mg one a day

  [These help prevent metastases from growing.]  Do not take with dairy, or minerals, they are not absorbed.  They interfere with oral contraception, too.

_____________________________________________________

2. Dexamethasone (Decadron) up to 4mg  every other day Antiangiogenic  reduces  inflammation & release of  free radicals.

[NOT FOR DIABETICS. May have side effects]

Be very cautious about the dexamethasone, it has serious side effects, and even in small doses be wary of it.

_______________________________________________________

3. Thalidomide       50mg ½ hour before bedtime

Antiangiogenesis.   Inhibits VEGF & bFGF & other mechanisms

Negative side effects include neuropathy in hands and feet, constipation, and sleepiness.

_______________________________________________________

4. Lovastatin or other statin drugs.    80mg a day for 3 weeks, and 2

weeks off and then repeat.

Turns on the tumor suppressor gene in cancer cells

Statins might lower levels of CoEnzyme Q10 in high doses..

_______________________________________________________

5. Squalamine 650 mg caps      1 three times a day

Antiangiogenesis & protects bone marrow during radiation.

Take either shark liver oil OR squalamine, not both.

_______________________________________________________

6. Retinoic acid (Vitamin A Factor-Accutaine) 10, 20, 40 mg capsules

0.5mg to 4.00mg per kg a day.  Requires a doctor’s supervision.

Affects the immune system, induces programmed cell death.

_______________________________________________________

7. Vitamin D3 analog 800 units a day

Antiangiogenesis, synergistic with vitamin A.

Makes Interferons work better

_______________________________________________________

*8. Etoposide      50mg cap One a day

Cytotoxic to endothelial cells*

See Metronomic Chemotherapy section

______________________________________________________

*9. Cytoxan 50mg    One tablet a day.

Same as 10 & elevates Thrombospondin 1

* See Metronomic Chemotherapy section

 ______________________________________________________

10. Methotrexate 2.5mg tablet, one a day

* See Metronomic Chemotherapy section

_______________________________________________________

11. Interferon Alpha  500,000 units I.M.  twice daily

[can be given as one injection of 1,000,000 units if tolerated.  Side

effects are “fluey” feelings.  If this occurs, try two injections a day of

500,000 each.]

_______________________________________________________

12. Tetrathiomolybdate   30mg   4X daily (1 with each meal  & at bedtime.

Do not take more than 50mg. of zinc with TM as copper ceruloplasm levels may fall too fast causing anemia. You need regular blood testing done weekly until the correct level of copper/zinc is reached. See section on TM

YOU MUST BE UNDER A DOCTOR”S SUPERVISION.  DO NOT USE CYTOTOXIC AGENTS UNLESS THERE IS TUMOR PRESENT.

Cytotoxics [chemotherapy agents]

These are potent drugs with dangerous side effects, and need careful doctor supervision.

Actually, the cytotoxics, cyclophosphamide and etoposide, are used to attack the normal endothelial cells that are growing toward the tumor, trying to supply the tumor with new blood vessels.  The daily low doses of these agents [called metronomic dosing] will damage/kill the rapidly dividing endothelial cells, and spare the rest of the body, including the tumor cells.  The cytotoxic agents are used if there is active disease, that is, if the patient is NOT in remission.  They are not used if the patient is in remission.

The cytotoxics are not being used in doses that approximate chemotherapy bolus dosing to shrink tumors, and the cytotoxics are not aimed at the tumor, but the endothelial cell.

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